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Research- Our Key Ingredients

Vitamin A

Cutis. 2010 Jul;86(1):47-52.Tretinoin for the treatment of photodamaged skin.Ting W.

Br J Dermatol. 2010 Mar;162(3):647-54.A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Fu JJ, et al.

Aesthet Surg J. 2010 Jan;30(1):74-7.Cosmeceuticals: the evidence behind the retinoids.Babamiri K, et al.

Clin Dermatol. 2008 Nov-Dec;26(6):633-5.Cosmeceuticals: focus on topical retinoids in photoaging. Serri R, et al.

J Drugs Dermatol. 2008 Jul;7(7 Suppl):s2-6.Topical vitamins.Burgess C. 

Vitamin B

Br J Dermatol. 2009 Dec;161(6):137-64 Topical nicotinamide modulates cellular energy metabolism and provides broad spectrum protection against UV-radiation-induced immunosuppression in humans. Sivapirabu G, et al.

 J Drugs Dermatol. 2008 Jul; 7(7 Suppl):s2-6. Topical Vitamins. Burgess C and Center for Dermatologic Surgery.

 J Investig Dermatol. 2008 Feb;128(2):447-54. UV radiation-induced immunosuprresion is greater in men and prevented by topical nicotinamide. Damian DL, and Melanoma and Skin Cancer Research Institute

 Cutis. 2006 Jan;771(1Suppl):11-6. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: A review. Niren NM

Dermatol Surg. 2005 Jul;31(7Pt 2):860-5; discussion 865. Niacinamide: A b vitamin that improved aging facial skin appearance. Bisset DL, et al.

 International J Cosemt Sci. 2004 Oct;26(5):231-8. Topical niacinamide reduces yellowing,wrinkling, red blotchinees, and hyperpigmented spots in aging facial skin. Bisset DL, et al.

FASEB J. 2003 Aug;17(11):1377-9. Nicotinamide: a potential addition to the anti-psoriatic weaponry. Namazi MR

 

Vitamin B5

Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):20-6. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. Jerajani HR, et al

Exp Dermatol. 2009 Sep;18(9):781-8. Epub 2009 Mar 23. Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin. Portugal-Cohen M, et al.

 

    Caffeine, Green Tea, White Tea

    Phytother Res. 2011 Apr 25. doi: 10.1002/ptr.3507. Photoprotective Effects of Topical Formulations Containing a Combination of Ginkgo biloba and Green Tea Extracts. Belo SE

     Dermat Treat. 2005;16(4):234-7. Evaluation of the efficacy of topical caffeine in the treatment of psoriasis vulgaris. Vali A, et al

     Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):234-42. Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Katiyar Sk, et al.

    Oncol Res. 2002;13(2):61-70. Stimulatory effect of topical application of caffeine on UV-induced apoptosis in mouse skin. Lu YP, et al.

    J Photochem Photobio B. 2001 Dec 31;65(2-3):109-Green Tea Polyphenols: DNA photdamage and photimmunology. Katiyar SK, et al.

     

    Coenzyme Q10

    Coll Antropol. 2010 Sep;34(3):1145-53. Modern approach to topical treatment of aging skin. Puizina-Ivić N, et al.

     Biofactors. 2008;32(1-4):237-43. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. Inui M, et al.

     J Cosmet Dermatol. 2006 Mar;5(1):30-8. Anti-inflammatory effects of CoQ10 and colorless carotenoids. Fuller B, et al.

     Biofactors. 1999;9(2-4):371-8. Coenzyme Q10, a cutaneous antioxidant and energizer. Hoppe U, et al.

    Vitamin E

    Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):20-6.The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. Jerajani HR, et al.

     Planta Med. 2010 Jun;76(9):869-75. Epub 2010 Jan 28. Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals. Makpol S, et al.

    Curr Probl Dermatol. 2001;29:157-64. Protective effects of topical antioxidants in humans. Dreher F, et al

    J Invest Dermatol. 1995 Apr;104(4):484-8. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. Jurkiewicz BA, et al.

     Photochem Photobiol. 1993 Aug;58(2):304-12.Evidence for the photoprotective effects of vitamin E. Fryer MJ.

    Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):20-6. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. Jerajani HR, et al

    Witch Hazel, Tea Tree Oil

    Forsch Komplementarmed Klass Naturheilkd. 2002 Jun;9(3):153-9. Antiseptic effect of a topical dermatological formulation that contains Hamamelis distillate and urea. Gloor M, et al.

     Skin Pharmacol Appl Skin Physiol. 2002 Mar-Apr;15(2):125-32. Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Hughes-Formella BJ, et al.

    Arch Dermatol Res. 2011 Jul;303(5):333-8. doi: 10.1007/s00403-010-1083-y. Tea tree oil attenuates experimental contact dermatitis. Wallengren J.

    J Craniomaxillofac Surg. 2009 Oct;37(7):392-7. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. Warnke PH, et al.

    Willow Bark

    Drug Test Anal. 2011 Jun;3(6):337-44. doi: 10.1002/dta.301. Early drug discovery and the rise of pharmaceutical chemistry. Jones AW

     Arzneimittelforschung. 2010;60(6):330-5. In vitro anti-proliferative effects of the willow bark extract STW 33-I. Bonaterra GA, et al.

    J Cosmet Dermatol. 2010 Sep;9(3):196-201. doi: 10.1111/j.1473-2165.2010.00512.x. An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging. Gopaul R, et al.

    Arzneimittelforschung. 2005;55(11):677-87. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Khayyal MT, et al.

    Resveratrol

    Nutr Cancer. 2011;63(1):28-38. Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants. Hanausek M, et al.

     Coll Antropol. 2010 Sep;34(3):1145-53. Modern approach to topical treatment of aging skin. Puizina-Ivić N, et al.

     Cancer Prev Res (Phila). 2010 Feb;3(2):170-8. Epub 2010 Jan 26. Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. Kowalczyk MC, et al.

     Pharm Res. 2009 Jan;26(1):211-7. Epub 2008 Sep 13. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Roy P, et al.

     Biol Pharm Bull. 2008 May;31(5):955-62. Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin. Hung CF, et al.

     Nat Rev Drug Discov 2006; 5 (6): 493–506. Therapeutic potential of resveratrol: the in vivo evidence. Baur JA, et al.

    Science 1997; 275 (5297): 218–20. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Jang M, et al.